Designing and Engineering Methylorubrum extorquens AM1 for Itaconic Acid Production
نویسندگان
چکیده
منابع مشابه
Metabolic engineering of Methylobacterium extorquens AM1 for 1-butanol production
BACKGROUND Butanol is a promising next generation fuel and a bulk chemical precursor. Although clostridia are the primary industrial microbes for the fermentative production of 1-butanol, alternative engineered hosts have the potential to generate 1-butanol from alternative carbon feedstocks via synthetic metabolic pathways. Methylobacterium extorquens AM1, a facultative methylotrophic α-proteo...
متن کاملBiochemistry of microbial itaconic acid production
Itaconic acid is an unsaturated dicarbonic acid which has a high potential as a biochemical building block, because it can be used as a monomer for the production of a plethora of products including resins, plastics, paints, and synthetic fibers. Some Aspergillus species, like A. itaconicus and A. terreus, show the ability to synthesize this organic acid and A. terreus can secrete significant a...
متن کاملItaconic Acid Production by Microorganisms: A Review
Itaconic acid (C5H6O4) is an organic acid with unique structure and characteristics. In order to promote the bio-based economy, the US-Department of Energy (DOE) assigned a “top-12” of platform chemicals, which include numerous of organic acids. In particular di-carboxylic acids, like itaconic acid, can be used as monomers for bio-polymers. Thus the need to produce itaconic acid attracts much a...
متن کاملProduction of 3-hydroxypropionic acid in engineered Methylobacterium extorquens AM1 and its reassimilation through a reductive route
BACKGROUND 3-Hydroxypropionic acid (3-HP) is an important platform chemical, serving as a precursor for a wide range of industrial applications such as the production of acrylic acid and 1,3-propanediol. Although Escherichia coli or Saccharomyces cerevisiae are the primary industrial microbes for the production of 3-HP, alternative engineered hosts have the potential to generate 3-HP from other...
متن کاملCo-Consumption of Methanol and Succinate by Methylobacterium extorquens AM1
Methylobacterium extorquens AM1 is a facultative methylotrophic Alphaproteobacterium and has been subject to intense study under pure methylotrophic as well as pure heterotrophic growth conditions in the past. Here, we investigated the metabolism of M. extorquens AM1 under mixed substrate conditions, i.e., in the presence of methanol plus succinate. We found that both substrates were co-consume...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2019
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.01027